Waterproof Personal Item

I usually travel with a small roller bag as my under seat personal item. I have had 3 of them ruined by the person in front of me either spilling liquid or vomiting (ick!!). Has anyone ever found a good option that is easy to clean? Mine are water resistant, but being fabric, they still absorb liquid when sitting in it for longer flights.

I have been down the Amazon rabbit hole for hours and am not having success with finding what I am looking for.