Any hope for running this MIDI keyboard properly in REAPER?

On a PC with Windows 10, my M-Audio Keystation 49e works when I use USB for power but doesn't respond to keyboard presses unless I connect the MIDI cable to my MIDI input on a MOTU M2 audio interface. It should only need the USB cable to work as a MIDI keyboard and controller.

1. Windows Device Manager can detect the M-Audio Keystation 49e, and going to Properties for the device I see it says "working properly" and the M-Audio driver is installed.
2. Can I use the M-Audio keyboard in standalone mode outside of REAPER? --Only when I connect a MIDI cable to the MOTU interface.
3. Can REAPER detect the M-Audio Keystation 49e? --Yes, but plugged in with only a USB cable, when I select "enabled" at MIDI device table it doesn't work. If I shut off the Keystation and reset MIDI devices, REAPER detects it's no longer present. The only way this works is by plugging the Keystation into the MOTU interface with a MIDI cable, and that works even when REAPER indicates the M-Audio Keystation is not present.
4. Is this a basic problem with the M-Audio driver? There is a driver that installed successfully, but it's a driver for Windows 7. No updates beyond that for the driver are available. I can find the driver in the Windows folder after install, but I can't select a "Run in Windows 7 compatibility mode" for it. I don't think this MIDI device is class compliant so it needs a manufacturer's driver.

In general I just wish I knew is it a Windows 10 problem or is it a problem with REAPER settings. If it's a problem with Windows 10, then it's going to be a problem with REAPER.