Pohx's private league - any recommendation for impending doom build?

Thinking of playing this skill because I've never tried using curses as a main damaging skill, especially after the rework a while ago. Totally, definitely not a commentary on the state of PoE 1. Has anyone played this build before or can give any recommendation? Probably occultist as the ascendancy, which means also using ES as the main defensive layer. Not sure which curses to use though.