Concerns for high COI. What’s the highest anyone has seen?

So we have 3 dogs, all from rescues that have varying degrees of inbreeding (0%, 27%, and 45%). None of them have any genetic markers noting any health issues. Are the 2 dogs with higher COIs more likely to have health or behavioral issues? What are the most common issues to look out for?

Also, and this is pure curiosity, does anyone have a dogs with a COI higher than 45%? If so, how old are they and how are they doing? Thank you!